human GLRX shRNA silencing AAV

Cat. No: shAAV-209995

Availability: 4-5 weeks

Name: AAV-h-GLRX-shRNA

This is an AAV expressing shRNA for silencing of Human GLRX.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GLRX
Gene Name: glutaredoxin
Gene ID: 2745
Gene Synonyms: GRX; GRX1
ORF Size: 321 bp
RefSeq#: NM_002064
Gene Description: GLRX encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
UniGene ID: Hs.712696
HGNC ID: HGNC:4330