human GJB1 shRNA silencing AAV

Cat. No: shAAV-209920

Availability: 6-8 weeks

Name: AAV-h-GJB1-shRNA

This is an AAV expressing shRNA for silencing of Human GJB1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GJB1
Gene Name: gap junction protein beta 1
Gene ID: 2705
Gene Synonyms: CMTX; CMTX1; CX32
ORF Size: 852 bp
RefSeq#: NM_000166
Gene Description: GJB1 encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
UniGene ID: Hs.715578
HGNC ID: HGNC:4283