human GJA1 shRNA silencing AAV

Cat. No: shAAV-209911

Availability: 4-5 weeks

Name: AAV-h-GJA1-shRNA

This is an AAV expressing shRNA for silencing of Human GJA1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GJA1
Gene Name: gap junction protein alpha 1
Gene ID: 2697
Gene Synonyms: AVSD3; CMDR; CX43; EKVP; GJAL; HLHS1; HSS; ODDD; PPKCA
ORF Size: 1149 bp
RefSeq#: NM_000165
Gene Description: GJA1 is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
UniGene ID: Hs.74471
HGNC ID: HGNC:4274