human GGCX shRNA silencing AAV

Cat. No: shAAV-209844

Availability: 4-5 weeks

Name: AAV-h-GGCX-shRNA

This is an AAV expressing shRNA for silencing of Human GGCX.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GGCX
Gene Name: gamma-glutamyl carboxylase
Gene ID: 2677
Gene Synonyms: VKCFD1
ORF Size: 2277 bp
RefSeq#: NM_000821
Gene Description: GGCX encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.77719
HGNC ID: HGNC:4247