human GADD45A shRNA silencing AAV

Cat. No: shAAV-209541

Availability: 4-5 weeks

Name: AAV-h-GADD45A-shRNA

This is an AAV expressing shRNA for silencing of Human GADD45A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GADD45A
Gene Name: growth arrest and DNA damage inducible alpha
Gene ID: 1647
Gene Synonyms: DDIT1; GADD45
ORF Size: 498 bp
RefSeq#: NM_001924
Gene Description: GADD45A is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
UniGene ID: Hs.80409
HGNC ID: HGNC:4095