human GABRD shRNA silencing AAV

Cat. No: shAAV-209521

Availability: 6-8 weeks

Name: AAV-h-GABRD-shRNA

This is an AAV expressing shRNA for silencing of Human GABRD.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GABRD
Gene Name: gamma-aminobutyric acid type A receptor delta subunit
Gene ID: 2563
Gene Synonyms: EIG10; EJM7; GEFSP5
ORF Size: 1359 bp
RefSeq#: NM_000815
Gene Description: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. The GABA-A receptor is generally pentameric and there are five types of subunits: alpha, beta, gamma, delta, and rho. This gene encodes the delta subunit. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures, type 5. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
UniGene ID: Hs.113882
HGNC ID: HGNC:4084