human FPGS shRNA silencing AAV

Cat. No: shAAV-209293

Availability: 4-5 weeks

Name: AAV-h-FPGS-shRNA

This is an AAV expressing shRNA for silencing of Human FPGS.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: FPGS
Gene Name: folylpolyglutamate synthase
Gene ID: 2356
ORF Size: 1764 bp
RefSeq#: NM_004957
Gene Description: FPGS encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
UniGene ID: Hs.335084
HGNC ID: HGNC:3824