human FAM125B shRNA silencing AAV

Cat. No: shAAV-208372

Availability: 4-5 weeks

Name: AAV-h-FAM125B-shRNA

This is an AAV expressing shRNA for silencing of Human MVB12B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: MVB12B
Gene Name: multivesicular body subunit 12B
Gene ID: 89853
Gene Synonyms: C9orf28; FAM125B
ORF Size: 666 bp
RefSeq#: NM_033446
Gene Description: FAM125B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.162659
HGNC ID: HGNC:23368