human EPOR shRNA silencing AAV

Cat. No: shAAV-208018

Availability: 6-8 weeks

Name: AAV-h-EPOR-shRNA

This is an AAV expressing shRNA for silencing of Human EPOR.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: EPOR
Gene Name: erythropoietin receptor
Gene ID: 2057
Gene Synonyms: EPO-R
ORF Size: 1527 bp
RefSeq#: NM_000121
Gene Description: EPOR encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
UniGene ID: Hs.631624
HGNC ID: HGNC:3416