human ENG shRNA silencing AAV

Cat. No: shAAV-207911

Availability: 4-5 weeks

Name: AAV-h-ENG-shRNA

This is an AAV expressing shRNA for silencing of Human ENG.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ENG
Gene Name: endoglin
Gene ID: 2022
Gene Synonyms: END; HHT1; ORW1
ORF Size: 1977 bp
RefSeq#: NM_000118
Gene Description: ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.76753
HGNC ID: HGNC:3349