human EIF2AK2 shRNA silencing AAV

Cat. No: shAAV-207705

Availability: 4-5 weeks

Name: AAV-h-EIF2AK2-shRNA

This is an AAV expressing shRNA for silencing of Human EIF2AK2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: EIF2AK2
Gene Name: eukaryotic translation initiation factor 2 alpha kinase 2
Gene ID: 5610
Gene Synonyms: EIF2AK1; PKR; PPP1R83; PRKR
ORF Size: 1656 bp
RefSeq#: NM_002759
Gene Description: EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
UniGene ID: Hs.131431
HGNC ID: HGNC:9437