human EGF shRNA silencing AAV

Cat. No: shAAV-207655

Availability: 6-8 weeks

Name: AAV-h-EGF-shRNA

This is an AAV expressing shRNA for silencing of Human EGF.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: EGF
Gene Name: epidermal growth factor
Gene ID: 1950
Gene Synonyms: HOMG4; URG
ORF Size: 3624 bp
RefSeq#: NM_001963
Gene Description: EGF encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
UniGene ID: Hs.419815
HGNC ID: HGNC:3229