human ECT2 shRNA silencing AAV

Cat. No: shAAV-207545

Availability: 4-5 weeks

Name: AAV-h-ECT2-shRNA

This is an AAV expressing shRNA for silencing of Human ECT2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ECT2
Gene Name: epithelial cell transforming 2
Gene ID: 1894
Gene Synonyms: ARHGEF31
ORF Size: 2652 bp
RefSeq#: NM_018098
Gene Description: ECT2 is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene.
UniGene ID: Hs.518299
HGNC ID: HGNC:3155