human DYRK1A shRNA silencing AAV

Cat. No: shAAV-207478

Availability: 4-5 weeks

Name: AAV-h-DYRK1A-shRNA

This is an AAV expressing shRNA for silencing of Human DYRK1A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DYRK1A
Gene Name: dual specificity tyrosine phosphorylation regulated kinase 1A
Gene ID: 1859
Gene Synonyms: DYRK; DYRK1; HP86; MNB; MNBH; MRD7
ORF Size: 2292 bp
RefSeq#: NM_001396
Gene Description: DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. DYRK1A is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
UniGene ID: Hs.368240
HGNC ID: HGNC:3091