human DUSP2 shRNA silencing AAV

Cat. No: shAAV-207424

Availability: 4-5 weeks

Name: AAV-h-DUSP2-shRNA

This is an AAV expressing shRNA for silencing of Human DUSP2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DUSP2
Gene Name: dual specificity phosphatase 2
Gene ID: 1844
Gene Synonyms: PAC-1; PAC1
ORF Size: 945 bp
RefSeq#: NM_004418
Gene Description: DUSP2 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
UniGene ID: Hs.1183
HGNC ID: HGNC:3068