human DPH1 shRNA silencing AAV

Cat. No: shAAV-207273

Availability: 4-5 weeks

Name: AAV-h-DPH1-shRNA

This is an AAV expressing shRNA for silencing of Human DPH1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DPH1
Gene Name: diphthamide biosynthesis 1
Gene ID: 1801
Gene Synonyms: DEDSSH; DPH2L; DPH2L1; OVCA1
ORF Size: 912 bp
RefSeq#: NM_001383
Gene Description: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 (PubMed 15485916)).(supplied by OMIM, Mar 2008)
UniGene ID: Hs.513856
HGNC ID: HGNC:3003