human DOK7 shRNA silencing AAV

Cat. No: shAAV-207251

Availability: 6-8 weeks

Name: AAV-h-DOK7-shRNA

This is an AAV expressing shRNA for silencing of Human DOK7.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DOK7
Gene Name: docking protein 7
Gene ID: 285489
Gene Synonyms: C4orf25; CMS10; CMS1B
ORF Size: 1515 bp
RefSeq#: NM_173660
Gene Description: DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
UniGene ID: Hs.701584
HGNC ID: HGNC:26594