human DNASE1 shRNA silencing AAV

Cat. No: shAAV-207186

Availability: 4-5 weeks

Name: AAV-h-DNASE1-shRNA

This is an AAV expressing shRNA for silencing of Human DNASE1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DNASE1
Gene Name: deoxyribonuclease 1
Gene ID: 1773
Gene Synonyms: DNL1; DRNI
ORF Size: 849 bp
RefSeq#: NM_005223
Gene Description: DNASE1 encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
UniGene ID: Hs.629638
HGNC ID: HGNC:2956