human DNAJC2 shRNA silencing AAV

Cat. No: shAAV-207160

Availability: 4-5 weeks

Name: AAV-h-DNAJC2-shRNA

This is an AAV expressing shRNA for silencing of Human DNAJC2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DNAJC2
Gene Name: DnaJ heat shock protein family (Hsp40) member C2
Gene ID: 27000
Gene Synonyms: MPHOSPH11; MPP11; ZRF1; ZUO1
ORF Size: 1866 bp
RefSeq#: NM_001129887
Gene Description: DNAJC2 is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. DNAJC2 has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described.
UniGene ID: Hs.558476
HGNC ID: HGNC:13192