human DIO2 shRNA silencing AAV

Cat. No: shAAV-206997

Availability: 4-5 weeks

Name: AAV-h-DIO2-shRNA

This is an AAV expressing shRNA for silencing of Human DIO2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DIO2
Gene Name: iodothyronine deiodinase 2
Gene ID: 1734
Gene Synonyms: 5DII; D2; DIOII; SelY; TXDI2
ORF Size: 822 bp
RefSeq#: NM_000793
Gene Description: DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniGene ID: Hs.708526
HGNC ID: HGNC:2884