human DDIT3 shRNA silencing AAV

Cat. No: shAAV-206706

Availability: 4-5 weeks

Name: AAV-h-DDIT3-shRNA

This is an AAV expressing shRNA for silencing of Human DDIT3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DDIT3
Gene Name: DNA damage inducible transcript 3
Gene ID: 1649
Gene Synonyms: CEBPZ; CHOP; CHOP-10; CHOP10; GADD153
ORF Size: 510 bp
RefSeq#: NM_004083
Gene Description: DDIT3 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
UniGene ID: Hs.690217
HGNC ID: HGNC:2726