human CYP7B1 shRNA silencing AAV

Cat. No: shAAV-206531

Availability: 6-8 weeks

Name: AAV-h-CYP7B1-shRNA

This is an AAV expressing shRNA for silencing of Human CYP7B1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CYP7B1
Gene Name: cytochrome P450 family 7 subfamily B member 1
Gene ID: 9420
Gene Synonyms: CBAS3; CP7B; SPG5A
ORF Size: 1521 bp
RefSeq#: NM_004820
Gene Description: CYP7B1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
UniGene ID: Hs.667720
HGNC ID: HGNC:2652