human CYP24A1 shRNA silencing AAV

Cat. No: shAAV-206462

Availability: 4-5 weeks

Name: AAV-h-CYP24A1-shRNA

This is an AAV expressing shRNA for silencing of Human CYP24A1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CYP24A1
Gene Name: cytochrome P450 family 24 subfamily A member 1
Gene ID: 1591
Gene Synonyms: CP24; CYP24; HCAI; HCINF1; P450-CC24
ORF Size: 1347 bp
RefSeq#: NM_000782
Gene Description: CYP24A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.89663
HGNC ID: HGNC:2602