human CYP1A2 shRNA silencing AAV

Cat. No: shAAV-206451

Availability: 4-5 weeks

Name: AAV-h-CYP1A2-shRNA

This is an AAV expressing shRNA for silencing of Human CYP1A2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CYP1A2
Gene Name: cytochrome P450 family 1 subfamily A member 2
Gene ID: 1544
Gene Synonyms: CP12; P3-450; P450(PA)
ORF Size: 1551 bp
RefSeq#: NM_000761
Gene Description: CYP1A2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
UniGene ID: Hs.1361
HGNC ID: HGNC:2596