human CYP19A1 shRNA silencing AAV

Cat. No: shAAV-206448

Availability: 6-8 weeks

Name: AAV-h-CYP19A1-shRNA

This is an AAV expressing shRNA for silencing of Human CYP19A1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CYP19A1
Gene Name: cytochrome P450 family 19 subfamily A member 1
Gene ID: 1588
Gene Synonyms: ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
ORF Size: 1512 bp
RefSeq#: NM_000103
Gene Description: CYP19A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
UniGene ID: Hs.260074
HGNC ID: HGNC:2594