human CXCR4 shRNA silencing AAV

Cat. No: shAAV-206344

Availability: 4-5 weeks

Name: AAV-h-CXCR4-shRNA

This is an AAV expressing shRNA for silencing of Human CXCR4.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CXCR4
Gene Name: chemokine (C-X-C motif) receptor 4
Gene ID: 7852
Gene Synonyms: CD184; D2S201E; FB22; HM89; HSY3RR; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM;
ORF Size: 1059 bp
RefSeq#: NM_003467
Gene Description: CXCR4 encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniGene ID: Hs.593413
HGNC ID: HGNC:2561