human SLC12A1 shRNA silencing AAV

Cat. No: shAAV-206288

Availability: 6-8 weeks

Name: AAV-h-SLC12A1-shRNA

This is an AAV expressing shRNA for silencing of Human SLC12A1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SLC12A1
Gene Name: solute carrier family 12 member 1
Gene ID: 6557
Gene Synonyms: BSC1; NKCC2
ORF Size: 3300 bp
RefSeq#: NM_000338
Gene Description: SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
UniGene ID: Hs.123116
HGNC ID: HGNC:10910