human CTTN shRNA silencing AAV

Cat. No: shAAV-206284

Availability: 4-5 weeks

Name: AAV-h-CTTN-shRNA

This is an AAV expressing shRNA for silencing of Human CTTN.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CTTN
Gene Name: cortactin
Gene ID: 2017
Gene Synonyms: EMS1
ORF Size: 1905 bp
RefSeq#: NM_005231
Gene Description: CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. CTTN has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
UniGene ID: Hs.596164
HGNC ID: HGNC:3338