human CTSL shRNA silencing AAV

Cat. No: shAAV-206277

Availability: 6-8 weeks

Name: AAV-h-CTSL-shRNA

This is an AAV expressing shRNA for silencing of Human CTSL.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CTSL
Gene Name: cathepsin L
Gene ID: 1514
Gene Synonyms: CATL; CTSL1; MEP
ORF Size: 1002 bp
RefSeq#: NM_001912
Gene Description: CTSL1 is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene.
UniGene ID: Hs.716407
HGNC ID: HGNC:2537