human CTPS2 shRNA silencing AAV

Cat. No: shAAV-206256

Availability: 4-5 weeks

Name: AAV-h-CTPS2-shRNA

This is an AAV expressing shRNA for silencing of Human CTPS2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CTPS2
Gene Name: CTP synthase 2
Gene ID: 56474
ORF Size: 1761 bp
RefSeq#: NM_019857
Gene Description: CTPS2 catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
UniGene ID: Hs.227049
HGNC ID: HGNC:2520