human CRKL shRNA silencing AAV

Cat. No: shAAV-206021

Availability: 4-5 weeks

Name: AAV-h-CRKL-shRNA

This is an AAV expressing shRNA for silencing of Human CRKL.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CRKL
Gene Name: CRK like proto-oncogene, adaptor protein
Gene ID: 1399
ORF Size: 912 bp
RefSeq#: NM_005207
Gene Description: CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
UniGene ID: Hs.592205
HGNC ID: HGNC:2363