human CRK shRNA silencing AAV

Cat. No: shAAV-206019

Availability: 4-5 weeks

Name: AAV-h-CRK-shRNA

This is an AAV expressing shRNA for silencing of Human CRK.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CRK
Gene Name: CRK proto-oncogene, adaptor protein
Gene ID: 1398
Gene Synonyms: CRKII; p38
ORF Size: 915 bp
RefSeq#: NM_005206
Gene Description: CRK encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
UniGene ID: Hs.638121
HGNC ID: HGNC:2362