human CRB1 shRNA silencing AAV

Cat. No: shAAV-205963

Availability: 6-8 weeks

Name: AAV-h-CRB1-shRNA

This is an AAV expressing shRNA for silencing of Human CRB1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CRB1
Gene Name: crumbs 1, cell polarity complex component
Gene ID: 23418
Gene Synonyms: LCA8; RP12
ORF Size: 4221 bp
RefSeq#: NM_201253
Gene Description: CRB1 encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.
UniGene ID: Hs.126135
HGNC ID: HGNC:2343