human COL2A1 shRNA silencing AAV

Cat. No: shAAV-205703

Availability: 6-8 weeks

Name: AAV-h-COL2A1-shRNA

This is an AAV expressing shRNA for silencing of Human COL2A1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: COL2A1
Gene Name: collagen type II alpha 1 chain
Gene ID: 1280
Gene Synonyms: ANFH; AOM; COL11A3; SEDC; STL1
ORF Size: 4464 bp
RefSeq#: NM_001844
Gene Description: COL2A1 encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
UniGene ID: Hs.408182
HGNC ID: HGNC:2200