human CLN6 shRNA silencing AAV

Cat. No: shAAV-205485

Availability: 4-5 weeks

Name: AAV-h-CLN6-shRNA

This is an AAV expressing shRNA for silencing of Human CLN6.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CLN6
Gene Name: ceroid-lipofuscinosis, neuronal 6, late infantile, variant
Gene ID: 54982
Gene Synonyms: CLN4A; HsT18960; nclf
ORF Size: 936 bp
RefSeq#: NM_017882
Gene Description: CLN6 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
UniGene ID: Hs.584921
HGNC ID: HGNC:2077