human CLDN1 shRNA silencing AAV

Cat. No: shAAV-205362

Availability: 6-8 weeks

Name: AAV-h-CLDN1-shRNA

This is an AAV expressing shRNA for silencing of Human CLDN1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CLDN1
Gene Name: claudin 1
Gene ID: 9076
Gene Synonyms: CLD1; ILVASC; SEMP1
ORF Size: 636 bp
RefSeq#: NM_021101
Gene Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
UniGene ID: Hs.439060
HGNC ID: HGNC:2032