human CLCNKB shRNA silencing AAV

Cat. No: shAAV-205361

Availability: 6-8 weeks

Name: AAV-h-CLCNKB-shRNA

This is an AAV expressing shRNA for silencing of Human CLCNKB.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CLCNKB
Gene Name: chloride voltage-gated channel Kb
Gene ID: 1188
Gene Synonyms: ClC-K2; ClC-Kb; CLCKB
ORF Size: 1389 bp
RefSeq#: NM_000085
Gene Description: CLCNKB is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.352243
HGNC ID: HGNC:2027