human CLCNKA shRNA silencing AAV

Cat. No: shAAV-205360

Availability: 6-8 weeks

Name: AAV-h-CLCNKA-shRNA

This is an AAV expressing shRNA for silencing of Human CLCNKA.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CLCNKA
Gene Name: chloride voltage-gated channel Ka
Gene ID: 1187
Gene Synonyms: ClC-K1; CLCK1; hClC-Ka
ORF Size: 2064 bp
RefSeq#: NM_004070
Gene Description: CLCNKA is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.591533
HGNC ID: HGNC:2026