human CITED4 shRNA silencing AAV

Cat. No: shAAV-205301

Availability: 6-8 weeks

Name: AAV-h-CITED4-shRNA

This is an AAV expressing shRNA for silencing of Human CITED4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CITED4
Gene Name: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
Gene ID: 163732
ORF Size: 555 bp
RefSeq#: NM_133467
Gene Description: The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.
UniGene ID: Hs.355820
HGNC ID: HGNC:18696