human IL17RA shRNA silencing AAV

Cat. No: shAAV-204946

Availability: 6-8 weeks

Name: AAV-h-IL17RA-shRNA

This is an AAV expressing shRNA for silencing of Human IL17RA.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: IL17RA
Gene Name: interleukin 17 receptor A
Gene ID: 23765
Gene Synonyms: CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R
ORF Size: 2601 bp
RefSeq#: NM_014339
Gene Description: Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.
UniGene ID: Hs.129751
HGNC ID: HGNC:5985