human CDKN2D shRNA silencing AAV

Cat. No: shAAV-204887

Availability: 4-5 weeks

Name: AAV-h-CDKN2D-shRNA

This is an AAV expressing shRNA for silencing of Human CDKN2D.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CDKN2D
Gene Name: cyclin dependent kinase inhibitor 2D
Gene ID: 1032
Gene Synonyms: INK4D; p19; p19-INK4D
ORF Size: 501 bp
RefSeq#: NM_079421
Gene Description: CDKN2D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
UniGene ID: Hs.435051
HGNC ID: HGNC:1790