human CDK5R1 shRNA silencing AAV

Cat. No: shAAV-204848

Availability: 4-5 weeks

Name: AAV-h-CDK5R1-shRNA

This is an AAV expressing shRNA for silencing of Human CDK5R1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CDK5R1
Gene Name: cyclin dependent kinase 5 regulatory subunit 1
Gene ID: 8851
Gene Synonyms: CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a
ORF Size: 924 bp
RefSeq#: NM_003885
Gene Description: CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
UniGene ID: Hs.500015
HGNC ID: HGNC:1775