human CDH1 shRNA silencing AAV

Cat. No: shAAV-204800

Availability: 4-5 weeks

Name: AAV-h-CDH1-shRNA

This is an AAV expressing shRNA for silencing of Human CDH1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CDH1
Gene Name: cadherin 1
Gene ID: 999
Gene Synonyms: Arc-1; CD324; CDHE; ECAD; LCAM; UVO
ORF Size: 1944 bp
RefSeq#: NM_004360
Gene Description: CDH1 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
UniGene ID: Hs.461086
HGNC ID: HGNC:1748