human CD4 shRNA silencing AAV

Cat. No: shAAV-204651

Availability: 6-8 weeks

Name: AAV-h-CD4-shRNA

This is an AAV expressing shRNA for silencing of Human CD4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CD4
Gene Name: CD4 molecule
Gene ID: 920
Gene Synonyms: CD4mut
ORF Size: 1377 bp
RefSeq#: NM_000616
Gene Description: CD4 encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. CD4 is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
UniGene ID: Hs.631659
HGNC ID: HGNC:1678