human CCL5 shRNA silencing AAV

Cat. No: shAAV-204464

Availability: 6-8 weeks

Name: AAV-h-CCL5-shRNA

This is an AAV expressing shRNA for silencing of Human CCL5.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CCL5
Gene Name: C-C motif chemokine ligand 5
Gene ID: 6352
Gene Synonyms: D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228
ORF Size: 276 bp
RefSeq#: NM_002985
Gene Description: CCL5 is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
UniGene ID: Hs.514821
HGNC ID: HGNC:10632