human CBS shRNA silencing AAV

Cat. No: shAAV-204180

Availability: 4-5 weeks

Name: AAV-h-CBS-shRNA

This is an AAV expressing shRNA for silencing of Human CBS.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CBS
Gene Name: cystathionine-beta-synthase
Gene ID: 875
Gene Synonyms: HIP4
ORF Size: 1656 bp
RefSeq#: NM_000071
Gene Description: CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
UniGene ID: Hs.533013
HGNC ID: HGNC:1550