human CBFA2T2 shRNA silencing AAV

Cat. No: shAAV-204157

Availability: 6-8 weeks

Name: AAV-h-CBFA2T2-shRNA

This is an AAV expressing shRNA for silencing of Human CBFA2T2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CBFA2T2
Gene Name: CBFA2/RUNX1 translocation partner 2
Gene ID: 9139
Gene Synonyms: EHT; MTGR1; p85; ZMYND3
ORF Size: 1845 bp
RefSeq#: NM_005093
Gene Description: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
UniGene ID: Hs.153934
HGNC ID: HGNC:1536