human CAV1 shRNA silencing AAV

Cat. No: shAAV-204148

Availability: 4-5 weeks

Name: AAV-h-CAV1-shRNA

This is an AAV expressing shRNA for silencing of Human CAV1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CAV1
Gene Name: caveolin 1
Gene ID: 857
Gene Synonyms: BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
ORF Size: 537 bp
RefSeq#: NM_001753
Gene Description: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
UniGene ID: Hs.74034
HGNC ID: HGNC:1527