human CAST shRNA silencing AAV

Cat. No: shAAV-204134

Availability: 6-8 weeks

Name: AAV-h-CAST-shRNA

This is an AAV expressing shRNA for silencing of Human CAST.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CAST
Gene Name: calpastatin
Gene ID: 831
Gene Synonyms: BS-17; PLACK
ORF Size: 2004 bp
RefSeq#: NM_173060
Gene Description: CAST is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
UniGene ID: Hs.436186
HGNC ID: HGNC:1515