human CASQ2 shRNA silencing AAV

Cat. No: shAAV-204130

Availability: 6-8 weeks

Name: AAV-h-CASQ2-shRNA

This is an AAV expressing shRNA for silencing of Human CASQ2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CASQ2
Gene Name: calsequestrin 2
Gene ID: 845
Gene Synonyms: PDIB2
ORF Size: 1200 bp
RefSeq#: NM_001232
Gene Description: CASQ2 specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
UniGene ID: Hs.57975
HGNC ID: HGNC:1513